WebFeb 12, 2014 · Designing drugs with a specific multi-target profile is a promising approach against multifactorial illnesses as Alzheimer's disease. In this work, new indazole ethers that possess dual activity as both cannabinoid agonists CB2 and inhibitors of BuChE have been designed by computational methods. On … Butyrylcholinesterase (HGNC symbol BCHE; EC 3.1.1.8), also known as BChE, BuChE, BuChase, pseudocholinesterase, or plasma (cholin)esterase, is a nonspecific cholinesterase enzyme that hydrolyses many different choline-based esters. In humans, it is made in the liver, found mainly in blood plasma, and … See more Butyrylcholinesterase may be a physiological ghrelin regulator. See more Pseudocholinesterase deficiency results in delayed metabolism of only a few compounds of clinical significance, including the following: succinylcholine, mivacurium, procaine, heroin, and cocaine. Of these, its most clinically important substrate is the … See more • Phytocannabinoids • Cymserine and derivatives • Profenamine • Rivastigmine • Tacrine See more • Bodur E, Cokugras AN (December 2005). "The effects of indole-3-acetic acid on human and horse serum butyrylcholinesterase". Chemico-Biological Interactions. … See more Click on genes, proteins and metabolites below to link to respective articles. See more The nomenclatural variations of BCHE and of cholinesterases generally are discussed at Cholinesterase § Types and nomenclature. See more • Cholinesterases • Dibucaine number See more
In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity …
WebOct 10, 2016 · Excessive hydrolysis of acetylcholine (ACh) and butyrylcholine (BCh) is one of the causes of neurodegenerative diseases, such as Alzheimer's disease (AD), … WebA novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s disease (AD). Most of the compounds showed weak to moderate activity … pcr for international travel perth
Identification of a Novel Dual Inhibitor of Acetylcholinesterase …
WebIntroduction: Butyrylcholinesterase (BuChE) has obtained a renewed interest as therapeutic target in Alzheimer's disease (AD), when changes in BuChE activity and expression along disease progression were highlighted as well as correlation between BuChE levels and cognitive function. WebAcetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these cholinesterases with uracil derivatives. WebMar 8, 2012 · Taking into account the above-mentioned issues, in view of the fact that some carbamates are also known from the literature to be active as FAAH inhibitors 21,22 and of the recent finding that the eCB anandamide and some of its congeners potently inhibit human plasma BuChE, 23 we decided to test the library 16−20 of carbamates that was … pcr form 2023