WebFunctionalization of amide bond via the cleavage of a non-carbonyl, C-N σ bond remains under-investigated. In this work, a transition-metal-free single-electron transfer reaction … WebTransition-metal-free catalytic protocols for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents enable the selective …
The pH dependent mechanisms of non-enzymatic peptide bond cleavage
WebEffect of the amino acid substituents on amide bond cleavage in N-acyl-a,a-dialkylglycine derivatives Wei-Qun Jiang,1 Susana P.G. Costa,1 Raquel M. Gonçalves-Maia,2 and Hernani L.S. Maia1 1Department of Chemistry, University of Minho, Gualtar, P-4710-320 Braga, Portugal; and 2Department of Chemistry and Biochemistry, Faculty of Science, … WebDec 22, 2024 · We developed a novel amide activation transformation to nitriles through inert C–C and C–N cleavage in good selectivity and yields. Utilizing simple and readily … databas historia
Catalytic Cleavage of Amide C-N Bond: Scandium
WebA novel approach for the efficient cleavage of the amide bonds in tertiary amides is reported. Based on the selective radical abstraction of a benzylic hydrogen atom by a CuBr _(2) /Selectfluor hybri WebAmide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and adopt particular three-dimensional structures, which, in turn, are responsible for their functions. … Web1 day ago · The primary product of NAT from a metal nitride to a C–H bond is a metal amide (that is, M–N (H)R), and subsequent electrophilic cleavage introduces the ultimate N-substituent: protonolysis... databasics convergint