Klf4 induction
WebJun 27, 2016 · A time-dependent reduction of KLF4 protein in DCs stimulated with either A. fumigatus or C. albicans was observed and significant after 12 and 24 h co-cultivation. The control stimulus LPS... WebAug 19, 2014 · Induction of KLF4 expression in ovarian cancer cells using lentiviral Tet-on vector. A. Lentiviral Tet-on vector system. Reverse transactivator (rtTA-M3) was driven by human ubiquitin C (UBC promoter), and EGFP or KLF4 was driven by the Dox inducible promoter TRE-tight. To induce the expression of EGFP or KLF4, Dox is required to activate …
Klf4 induction
Did you know?
WebNov 12, 2024 · Klf4 pluripotency Introduction The first demonstration that differentiated somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) utilized … WebApr 18, 2024 · In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer.
WebKLF4 also known as gut-enriched Kruppel-like factor or epithelial zinc finger, is a 470 amino acid protein that is centrally distributed in epithelial cells of the gastrointestinal tract. ... The aberrant expression of Gli1, which can interact with HDAC1, leads to the induction of cancers [93], [135]. Furthermore, TGF-β has been found to ... WebApr 10, 2024 · KLF4 contains an activation domain as well as a repression domain 21 and is therefore able to induce and suppress the transcription of different genes including molecules involved in the...
WebInduction of aberrant DNA methylation is the major pathway by which H. pylori infection induces gastric cancer, and this can be utilized for translational opportunities. ... Krüppel‐like factor 4 (KLF4) has a tumor suppressor role in the progression of gastric cancer (GC), and inhibition or loss of KLF4 expression was identified in GC. ... WebJun 2, 2009 · To identify a chemical replacement for Klf4, NL-MEFs were transduced with a subset of reprogramming factors comprising Oct4, Sox2, and c-Myc (OSM). To obtain the ≈10 9 cells needed to screen large chemical libraries required expansion of OSM-transduced NL-MEFs for 3 passages before screening.
WebApr 8, 2024 · KLF4 is a prominent member of this family, and embryonic deletion of KLF4 leads to alterations in skin permeability and postnatal death. ... Gagea M, Li Z, et al. KLF4 Is Essential for Induction ...
WebDec 26, 2024 · The rapid induction of Klf4 expressions by LH was observed in preovulatory GCs. To evaluate whether Klf4 affects GC proliferation and survival, primary rat GCs were isolated from pregnant mare serum gonadotropin-primed Sprague–Dawley rat ovaries and transfected with a Klf4 expression vector or Klf4 -specific siRNA, followed by … jelena vlajicWebSep 3, 2024 · In this Klf4∆Pod murine model of proliferative glomerulopathy, podocyte-specific knockdown of Klf4 induces podocyte loss and triggers PEC activation and … jelena vlahović disertacijaWebMay 15, 2008 · Induction of Klf4 expression following vascular injury was abolished in conditional Klf4 -deficient mice. A, Experimental protocol showing the timing of 4-OHT injection, ligation injury, and harvesting tissues. lahore to gujranwala train timingWebInduction of colitis and treatment. ... KLF4 is a zinc finger transcription factor expressed in differentiated epithelial cells of the intestine and is widely involved in the regulation of cell proliferation, differentiation and embryonic development, ... lahore to dubai ticket price in pakistani rupeesWebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and colon cancer. 13 Therefore, KLF4 is a potential diagnostic marker, prognostic factor, or target for novel therapy. To the authors’ knowledge, this is the first study to ... jelena volicWebJun 8, 2015 · The expression of KLF4 is positively regulated by ERK in tumor cells from several origins, 15, 26 and it is considered to be involved in monocytic differentiation of myeloid cells. 16 When we... jelena vlašić duićWebKlf4 encodes Krueppel-like factor 4 (Klf4), a zinc finger transcription factor that is evolutionarily conserved from flies to humans. Klf4 is reported to be expressed in the … jelena vucenovic