Metabolites gwas
Web6 uur geleden · The team then compared the discovered genes with data from genome-wide association studies (GWAS) of human height. GWAS allows researchers to survey the entire human genome to identify hotspots ... Web4 apr. 2024 · Pleiotropy and genetic correlation are widespread features in GWAS, but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino acid catabolism, glycolysis, and ketone body metabolism in a subset of UK Biobank.
Metabolites gwas
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Web20 okt. 2024 · Few studies have explored the impact of rare variants (minor allele frequency, MAF<1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple … Web12 jan. 2024 · Our GWAS results provide insights into the genetic architecture of metabolite levels. Over 50% of tested metabolites within each superpathway had independent variant–metabolite associations,...
Web7 apr. 2024 · The structure of the maize kernels plays a critical role in determining maize yield and quality, and high-throughput, non-destructive microscope phenotypic characteristics acquisition and analysis are of great importance. In this study, Micro-CT technology was used to obtain images of maize kernels. An automatic CT image analysis … Web30 mrt. 2024 · Genome-wide association studies (GWAS) have had limited success in identifying genetic factors that predict kidney disease progression, despite major financial investment and the study of more ...
Web30 apr. 2012 · Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of … WebMetabolic genome-wide association study (mGWAS) is one of the most powerful tools for global identification of genetic determinants for diversity of plant metabolism. Recently, mGWAS has been performed for various species with continuous …
WebRecently, metabolomics GWAS was performed to identify genomic regions associated with variation in milk metabolites in dairy cattle (Buitenhuis et al., 2013). To the best of our knowledge, this study is the first attempt at profiling the genetic basis of plasma …
Web28 mrt. 2024 · A genome-wide association study (GWAS) with 7824 participants provided data on 486 human blood metabolites. Outcome information was obtained from a large-scale GWAS meta-analysis of NAFLD, which contained 8,434 cases and 770,180 controls of … optometrist in elizabethton tnWebIn this study, genome-wide association studies (GWAS) were conducted to investigate the genetic architecture behind the natural variation of rice secondary metabolites. GWAS using the metabolome data of 175 rice accessions successfully identified 323 … optometrist in fullerton caWeb12 apr. 2024 · GWAS summary data of a total of 17 independent studies related to allergic diseases were collected from the IEU GWAS database for the outcome dataset. Significant causal relationships were obtained between gut microbiome features including Ruminococcaceae, Eggerthella, Bifidobacterium, Faecalibacterium, and Bacteroides and … portrait of venusWeb10 sep. 2024 · We performed a genome-wide association study (GWAS) on the levels of 340 lipid metabolites using 6.7 million imputed autosomal variants in 5662 hospital-based controls from PROMIS. We applied DIHRMS to quantify serum lipid metabolites across … optometrist in gaboroneWe first performed GWAS of the 158 serum metabolites. These measurements consisted of 98 lipoproteins components (42 very-low-density lipoprotein (VLDL), 7 IDL, 21 low-density lipoprotein (LDL) and 28 high-density lipoprotein (HDL)), 9 amino acids, 16 fatty acids, and 35 other molecules … Meer weergeven We observed substantial evidence of polygenicity and pleiotropy. Using the aforementioned SNP-gene assignment, 147 … Meer weergeven An important component of the METSIM cohort is the collection of statin use among participants. To examine changes in genetic … Meer weergeven For pleiotropic genes, we observed heterogeneity in the number of reported top SNP across metabolites (Fig. 4b). For example, the top SNP for APOC1 was the same across … Meer weergeven Another unique aspect of the METSIM cohort is a second measurement of the same metabolites, using the same technology, ~ … Meer weergeven optometrist in grass valley caWebThe utility of maize metabolite GWAS was demonstrated by confirming known benzoxazinoid biosynthesis genes, as well as by mapping isomeric variation in the accumulation of phenylpropanoid hydroxycitric acid esters to a single linkage … portrait of vWeb27 feb. 2024 · Genetic correlations of metabolite with CBC traits and single step genome-wide association study (ssGWAS) were estimated using the BLUPF90 programs. Results: Results showed low phenotypic correlation estimates between plasma metabolites and … optometrist in garden city ny