Pear1 ipf
WebMay 22, 2024 · PEAR1 is a type of receptor tyrosine kinase (RTK) causing platelet- platelet adhesion via the EMI domain (EMILIN Family Domain) in its extracellular part and … WebAug 18, 2016 · PEAR1 encodes a transmembrane tyrosine kinase receptor expressed in platelets and endothelial cells and plays a role in platelet cell activation. 2 Discovered in 2005, PEAR1 was found to be phosphorylated following platelet aggregation in a proteomic screen. 2 Subsequently, we and others found association of common genetic variants in …
Pear1 ipf
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WebIdiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with an unclear pathogenesis. This study aimed to elucidate the function and potential mechanisms of … WebMay 22, 2024 · PEAR1 is a type of receptor tyrosine kinase (RTK) causing platelet- platelet adhesion via the EMI domain (EMILIN Family Domain) in its extracellular part and triggering PI3K/AKT/PTEN signaling, which leads to PEAR1-mediated stimulation of megakaryopoiesis and neoangiogenesis [ 5, 14 ].
WebPEAR1 encodes a deduced 1,037-amino acid protein with a molecular mass of 150 kD measured by Western blot. PEAR1 contains a predicted transmembrane domain, an NPXY motif (interaction site for PTB domain-containing proteins), 15 EGF-like repeats in its extracellular domain, and 5 proline-rich domains in its intracellular domain. WebJan 31, 2024 · The culture supernatants of LFs from IPF patients, as compared to controls, showed an increase in plasmin activity after plasminogen incubation (5–15 μg/mL), corresponding with increased levels ...
WebNov 19, 2024 · PEAR1 belongs to a unique family of EGF (epidermal growth factor) repeat-containing transmembrane proteins 10, and is majorly expressed in endothelial cells and platelets 10 – 13. The high-affinity immunoglobulin E receptor α (FcεR1α) has been identified as a natural ligand for human PEAR1. WebJul 8, 2015 · PEAR1 expression in human ECs. (A) Immunohistochemical staining for PEAR1 and CD31, illustrating PEAR1-protein expression in ECs of human liver, lung, and kidney, as indicated (×100 left panel, ×1000 middle panel, and ×100 right panel).(B) IF staining (×630) for CD31 (red), PEAR1 (green), and merge (white colour represents the calculated overlap) …
WebOct 29, 2024 · After exclusion of failing samples, a total of 605 Moli-family participants were included for further analyses. Mean and SD of PEAR1 CpG sites methylation ranged from 0.6 ± 1.0% for CpG28–29 up to 90.8 ± 14.1% for CpG17. Only CpG7–8, 17, and 27 had methylation averages across the population higher than 10%, while all the other 13 CpG …
WebApr 26, 2012 · PEAR1 (platelet endothelial aggregation receptor-1; also known as MEGF12 or JEDI) is a transmembrane protein of the multiple epidermal growth factor (EGF)–like domain protein family, first described in 2005. 1 PEAR1 is mainly expressed in platelets and endothelial cells, as well as satellite glial cell precursors, where it is necessary for … cleared to workWebThe Provider Engagement, Analytics & Reporting (PEAR) portal offers participating providers* a single point of entry to multiple digital tools: PEAR Analytics & Reporting … cleared vs approvedWeb cleared weeds crosswordWebPEAR1 regulates fibro- blast activation by associating with Protein Phosphatase 1 to suppress fibrotic factors-induced intracellular signaling. Importantly, mono- clonal … cleared vs reconciledWebNov 25, 2024 · Platelet endothelial aggregation receptor-1 (PEAR1), expressed in endothelium, platelets, and other tissues, is a platelet transmembrane tyrosine kinase receptor involved in platelet aggregation and platelet-platelet contact. The minor allele (A) in intron 1 of the PEAR1 gene (rs12041331, G>A) is associated with an reduced PEAR1 … cleared virtual diversity event march 2 2022WebSep 22, 2011 · With the use of fine mapping of the PEAR1 locus and sequencing of the PEAR1 gene, we have now identified a common variant (rs12041331, genetic location chromosome 1: 155136338, NCBI build 36.3) in intron 1 of PEAR1 that accounts most strongly for the association signal between the PEAR1 locus and platelet function … blue light pledgeWebContact information provided for "Support Groups" listed on this website is solely intended for patients, caregivers, and family members who would like to participate in a support … cleared via