Slc11a1 rs7608307
WebJan 1, 2009 · Slc11a1 enhanced Th1-mediated response to HEL immunization. Slc11a1 is proinflammatory, but it is not clear whether Slc11a1 directly affects the production of inflammatory cytokines by DCs and macrophages or through indirect activation of T-cells. Nevertheless, enhanced Th1 bias would accelerate autoimmune destruction in the … WebApr 1, 2013 · SLC11A1 is a 90–100 kDa integral transmembrane protein expressed in the lysosomal compartment of macrophages and in tertiary granules of neutrophils. The human SLC11A1 gene was cloned, and localized to the long arm of chromosome 2 (2q35).
Slc11a1 rs7608307
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WebDec 7, 2007 · Slc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells. The mode of action of the two transporters remains controversial. Heterologous expression in frog oocytes s … WebJan 25, 2011 · Background Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations. …
WebFeb 9, 2024 · SLC11A1 is located in monocyte phagolysosomes that help to limit M. tuberculosis growth by transferring divalent cations across the membrane. Web3'UTR of bovine SLC11A1 modulates gene expression and subsequent disease resistance in a phase dependent manner. The results of this study demonstrate that there are seventy-five total single nucleotide polymorphic (SNP) sites (excluding indels) located within the bovine genomic SLC11A1 sequence of a Brucella abortus resistant bull and a ...
WebApr 15, 2013 · Solute carrier 11A1 (SLC11A1) is a divalent ion transporter formerly known as the natural resistance-associated macrophage protein (NRAMP1) and the Bcg/Lsh/Ity locus. SLC11A1 was thought to be exclusively expressed in monocyte/macrophages and to have roles in phagosome maturation and cell activation. WebSLC7A11 (also known as XCT) is a member of a hetromeric, sodium-independent, anionic amino acid transport system. It is highly specific for cysteine and glutamate. SLC7A11 is …
Webof SLC11A1 gene is very important due to its association with resistance/ susceptibility to various intracellular pathogens in human as well as in livestock species. The SLC11A1 gene, formerly known as natural resistance-associated macrophage protein 1 (NRAMP1) encodes an integral membrane protein regulating the activity of macrophages.
WebJan 1, 2009 · Slc11a1 is proinflammatory, but it is not clear whether Slc11a1 directly affects the production of inflammatory cytokines by DCs and macrophages or through indirect … red moon 2018WebJul 22, 2024 · SLC11A1 was identified as a proton cation antiporter, which localizes to lysosomes or late endosome. It has been reported that SLC11A1 regulates macrophage … red moon 2015WebCurrent Weather. 6:40 AM. 46° F. RealFeel® 50°. Air Quality Poor. Wind NE 1 mph. Wind Gusts 4 mph. Partly cloudy More Details. richard swanson dentist crystal river flWebThis gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions … red moon 2016WebSLC11A1 (formerly Human natural resistance–associated macrophage protein 1 (NRAMP1)) has been associated with susceptibility to tuberculosis. 94 The importance of … richard swanson dds dmd crystal river flWeb(317) 888-8236. Pat. Five Star South 1195 N Madison Avenue Greenwood, IN 46142 E. of Greenwood Park Mall richard swanson greensboro ncWebMar 9, 2024 · The Slc11a1 encodes a late endosomal/lysosomal protein/divalent cation transporter, which regulates iron homeostasis in macrophages. results demonstrate a … richard swanson dds